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2018 Mar 26
Smiles: CC1=CC=C(O1)C1NC2=CC=CC=C2N2C(=C3C(=C21)N(C)C(=O)N(C)C3=O)C1C=CC=CC=1
62(19):8784-8795
1H3/b20-14+
SGX-523 - CAS# 1022150-57-7 Size:Solid 10 mg 2018 Mar 26SGX523 is a novel, ATP competitive kinase inhibitor remarkable for its exquisite selectivity for MET. SGX523 potently inhibited MET with an IC50 of 4 nmol L and is >1,000 fold selective versus the >200 fold selectivity of other protein kinases tested in biochemical assays. Crystallographic study revealed that SGX523 stabilizes MET in a unique inactive conformation that is inaccessible to other protein kinases, suggesting an explanation for the
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