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2013 Sep 4
453 produces sustained responses in a similar concentration range to those observed with acute stimulation (a small 1
PubMed PMID: 21439936
4)oxaazacyclotricosine-1
PF-4136309 - CAS# 1341224-83-6 273 2013 Sep 4PF 4136309, CAS No. 1341224 83 6, also known as INCB8761, is an orally available human chemokine receptor 2 (CCR2) antagonist with potential immunomodulating and antineoplastic activities. Upon oral administration, CCR2 antagonist PF 04136309 specifically binds to CCR2 and prevents binding of the endothelium derived chemokine ligand CLL2 (monocyte chemoattractant protein 1 or MCP1) to its receptor CCR2, which may result in inhibition of CCR2
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