K-Ras ligand-Linker Conjugate 4 Catalog No.:M14597-2 Pazopanib potently inhibits VEGF-induced phosphorylation

Pazopanib potently inhibits VEGF-induced phosphorylation of VEGFR2 in HUVEC cells with IC50 of 8 nM

a furocoumarin naturally occurring tricyclic aromatic compound

CC1=CN=C(CS(=O)C2[N-]C3=CC=C(C=C3N=2)OC)C(C)=C1OC

InChi: InChI=1S/C24H30N2O2/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27

K-Ras ligand-Linker Conjugate 4 Catalog No.:M14597-2 Pazopanib potently inhibits VEGF-induced phosphorylationK Ras ligand Linker Conjugate 4 incorporates a ligand for K Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K Ras ligand Linker Conjugate 4 can be used in the synthesis of PROTAC K Ras Degrader 1 (HY 129523), which is potent PROTAC K Ras degrader that exhibits 70% degradation efficacy in SW1573 cells. Product information CAS Number: 2378261 83 5 Molecular Weight: 697. 82 Formula: C35H51N7O8