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PMID: 31927622
Chemical Name: 3-((6-(4
InChiKey: IHIUGIVXARLYHP-UXNJHFGPSA-N
3-dihydrobenzo(b)(1
RAF265 enafil dihydrochloride PMID: 31927622CHIR 265 is an orally bioavailable small molecule with potential antineoplastic activity. CHIR 265 binds and inhibits Raf kinases, which may result in a reduction of tumor cell growth and proliferation, and tumor cell death. In addition, this agent inhibits vascular endothelial growth factor receptor type 2 (VEGFR 2), thereby disrupting tumor angiogenesis. Raf kinases are critical enzymes in the Ras Raf MEK ERK signaling pathway and are frequently
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