TAK-875 (Fasiglifam) - GPR40 Agonist. CAS# 1374598-80-7 0083 Smiles: CC1=CC=C(Cl)C=C1N(CC(=O)NC1C(F)=CC=CC=1F)S(C)(=O)=O

Smiles: CC1=CC=C(Cl)C=C1N(CC(=O)NC1C(F)=CC=CC=1F)S(C)(=O)=O

PubMed PMID: 26506839

It blocks adipogenesis by inhibiting the activation of SREBP-1 and SREBP-2

A combination of YM-155

TAK-875 (Fasiglifam) - GPR40 Agonist. CAS# 1374598-80-7 0083 Smiles: CC1=CC=C(Cl)C=C1N(CC(=O)NC1C(F)=CC=CC=1F)S(C)(=O)=OTAK 875 (Fasiglifam), CAS No. 1374598 80 7, is the potent, selective and orally bioavailable partial GPR40 agonist with an EC50 ~14 nM. It has binding affinity to the human GPR40 receptor with Ki of 38 nM and the rat GPR40 receptor with Ki of 140 nM. TAK 875 has no agonist potency to other members of the FFA receptor family with EC50 >10 M. The 2. 3 resolution co complex structure of hGPR40 TAK 875 reveals a unique binding mode of TAK 875 and suggests