As a rule of thumb, the more aggressive your deck is or the more it cares about playing to the board, the fewer board wipes you should run , while combo or control decks that dont care much about amassing creatures get away with running more
Worldly Tutor, Gamble, Crop Rotation, Intuition, and Natural Order all moved to the Game Changers list, which means most of the really good tutors are now restricted in this way
Youll find Sol Ring, Arcane Signet, and Talisman of Indulgence as great ramp additions, and a number of Rakdos staples like Bedevil, Rakdos Charm, and Terminate also make their way into the 99
One ripple effect of Wizards focus on Commander has been a sharp uptick in the number of legendary creatures in each MTG set