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CAS Number: 1146963-51-0
9)10/h2-16H
Molecular Weight: 489
Bortezomib or Imatinib for synergistic activity
GDC-0941 - PI3K Inhibitor. CAS# 957054-30-7 size:2 mg solid CAS Number: 1146963-51-0GDC 0941, CAS No. 957054 30 7, is a highly potent, selective and orally bioavailable class I PI3K kinase inhibitor. Its IC50 for PI3K p110 , , and isoforms are 3 nM, 33 nM, 3 nM, and 75 nM, respectively; and its IC50 for DNA PK and mTOR are 1230 nM and 580 nM. It potently inhibits the phosphorylation of Akt in U87MG, PC3, and MDA MB 361 cells with IC50 of 46 nM, 37 nM, and 28 nM, respectively. It also inhibits the proliferation of U87MG, A2780, PC3,
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