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The WD40-repeat protein WDR5 plays a critical role in maintaining the integrity of the MLL complex and fully activating its methyltransferase function
Molecular Weight: 544
arenaviruses
PubMed PMID: 25516695
BO-264 - CAS# 2408648-20-2 Catalog No.:M7012-2 The WD40-repeat protein WDR5 playsBO 264, CAS No. 2408648 20 2, is a highly potent and orally active transforming acidic coiled coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1. 5 nM. BO 264 demonstrated superior anti proliferative activity to the two currently reported TACC3 inhibitors, especially in aggressive breast cancer subtypes, basal and HER2+, via spindle assembly checkpoint (SAC) dependent mitotic arrest, DNA damage and apoptosis, while the cytotoxicity against
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